Talin2抗体—艾普蒂 新品

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     Western blot analysis of Talin 2 in expression HeLa cell lysate.    

  
  

Talin2 antibodies are immunological tools specifically designed to detect and study the Talin2 protein, a key component in cellular adhesion and signaling processes. Talin2. a paralog of Talin1. is a large cytoskeletal protein that plays a critical role in linking integrin receptors to the actin cytoskeleton, facilitating cell-matrix adhesion and mechanotransduction. It is enriched in tissues such as the brain, kidney, and heart, where it regulates focal adhesion dynamics, cell migration, and membrane stability. Unlike Talin1. which is ubiquitously expressed, Talin2 exhibits tissue-specific functions and may compensate for Talin1 in certain contexts.

Talin2 antibodies are commonly generated in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies are validated for applications such as Western blotting, immunofluorescence, immunohistochemistry, and co-immunoprecipitation to assess Talin2 expression, localization, and interactions. High-quality Talin2 antibodies demonstrate specificity by distinguishing Talin2 from Talin1 and showing minimal cross-reactivity in knockout controls.

Research utilizing Talin2 antibodies has advanced understanding of its involvement in diseases, including cancer metastasis, neurological disorders, and cardiovascular pathologies. By enabling precise detection of Talin2 in cellular and tissue models, these antibodies help uncover its regulatory mechanisms in adhesion complexes, offering potential therapeutic targets for adhesion-related diseases. Validation through knockdown/knockout experiments remains essential to confirm antibody reliability.