TACC3抗体—艾普蒂

The TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) antibody is a research tool designed to target the TACC3 protein, a member of the TACC family involved in critical cellular processes such as mitotic spindle assembly, centrosome dynamics, and microtubule stabilization. TACC3 is predominantly expressed during mitosis and plays a role in cell cycle regulation, particularly in chromosome segregation and cytokinesis. Dysregulation of TACC3 has been linked to various cancers, including breast, ovarian, and lung cancers, where its overexpression correlates with tumor aggressiveness and poor prognosis. The antibody, typically developed as polyclonal or monoclonal, is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study TACC3's expression patterns, subcellular localization, and interaction partners. Recent studies highlight its involvement in cancer stem cell maintenance, DNA damage response, and epigenetic regulation, making it a potential therapeutic target. Additionally, TACC3 antibodies aid in exploring its role in developmental processes and neurological disorders. Validating antibody specificity remains crucial, as cross-reactivity with other TACC family members (TACC1/2) can occur. Overall, TACC3 antibodies are essential for deciphering the protein's biological functions and its implications in disease mechanisms.