MRRF抗体—艾普蒂

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of MRRF expression in HeLa cell lysate.    

  
  

**Background of MRRF Antibody**

The **mitochondrial ribosome recycling factor (MRRF)**, also known as mitochondrial translation release factor 1. is a critical protein involved in mitochondrial translation and ribosome recycling. It facilitates the release of ribosomes from mRNA after translation termination, ensuring efficient protein synthesis within mitochondria. MRRF interacts with mitochondrial ribosomes and other translation factors to maintain the integrity of mitochondrial gene expression, which is essential for oxidative phosphorylation (OXPHOS) and cellular energy production.

MRRF antibodies are immunological tools designed to detect and study the expression, localization, and function of MRRF in various biological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate mitochondrial dysfunction linked to diseases such as neurodegenerative disorders, metabolic syndromes, and cancer. Mutations or dysregulation of MRRF have been implicated in impaired mitochondrial translation, leading to reduced ATP synthesis and increased oxidative stress.

Research utilizing MRRF antibodies has advanced understanding of mitochondrial ribosome dynamics, highlighting their role in cellular homeostasis and disease pathogenesis. Validated for specificity and sensitivity, these antibodies are crucial for exploring molecular mechanisms underlying mitochondrial disorders and evaluating potential therapeutic targets. Their application bridges basic mitochondrial biology with clinical insights into energy metabolism-related pathologies.