SATB1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09243(ZNF43 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P09243(ZNF43 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

SATB1 (Special AT-rich Sequence Binding Protein 1) is a nuclear matrix protein that plays a critical role in chromatin organization and transcriptional regulation. It binds to AT-rich DNA sequences, facilitating higher-order chromatin remodeling and modulating gene expression programs involved in cell differentiation, immune response, and oncogenesis. SATB1 is particularly notable for its role in T-cell development and its dual function in cancer, acting as both a tumor suppressor and promoter depending on cellular context.

SATB1 antibodies are essential tools for studying its expression, localization, and functional mechanisms. These antibodies are widely used in techniques such as Western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specificity validation, including knockout controls, is crucial due to potential cross-reactivity with homologous proteins like SATB2. Most commercial SATB1 antibodies are raised against epitopes in its N-terminal or C-terminal regions, with common host species being rabbit or mouse.

Research applications often focus on SATB1's association with cancer progression (e.g., breast, colorectal, and gastric cancers), where its overexpression correlates with metastasis and poor prognosis. Conversely, reduced SATB1 levels are linked to autoimmune disorders and immunodeficiency. Recent studies also explore its epigenetic regulatory functions and therapeutic targeting potential. Proper experimental optimization, including tissue fixation methods and antibody dilution, is critical for reliable results. Key studies by Cai et al. (2006) and Han et al. (2008) established SATB1's role in oncogenesis, driving continued antibody development for diagnostic and mechanistic investigations.