Phospho-PP2Aalpha(Y307)抗体—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human cerebrum tissue lysate, Primary antibody: P09223(ZKSCAN1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09223(ZKSCAN1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The Phospho-PP2Aalpha(Y307) antibody is a specialized tool used to detect the phosphorylation status of the alpha catalytic subunit of Protein Phosphatase 2A (PP2A) at tyrosine residue 307. PP2A is a highly conserved serine/threonine phosphatase critical for regulating diverse cellular processes, including cell cycle progression, signal transduction, and apoptosis. Its activity is tightly controlled by post-translational modifications, such as phosphorylation, and interactions with regulatory subunits.

Phosphorylation at Y307 in PP2Aalpha (encoded by PPP2CA) has been implicated in modulating PP2A’s enzymatic activity and substrate specificity. Studies suggest that phosphorylation at this site may alter PP2A’s conformation, potentially disrupting its binding to regulatory B subunits or influencing its association with other signaling complexes. This modification has been linked to pathological conditions, including cancer and neurodegenerative diseases, where dysregulated PP2A activity contributes to aberrant signaling.

The Phospho-PP2Aalpha(Y307) antibody enables researchers to investigate the dynamic regulation of PP2A in response to cellular stimuli or stress, providing insights into its role in health and disease. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess PP2A activation states in experimental models. Understanding Y307 phosphorylation may aid in developing therapeutic strategies targeting PP2A-related pathways.