MKLP1抗体—艾普蒂 新品

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of MKLP1 expression in HeLa cell lysate.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:50 dilution.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:50 dilution.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:150 dilution.    

  
  

The MKLP1 (Mitotic Kinesin-Like Protein 1) antibody is a tool used to detect and study the MKLP1 protein, a member of the kinesin superfamily involved in cell division. MKLP1. also known as KIF23. plays a critical role in cytokinesis by facilitating the formation and constriction of the midbody, a transient structure essential for separating daughter cells during mitosis. It interacts with the centralspindlin complex, contributing to microtubule organization and ensuring proper chromosomal segregation. Dysregulation of MKLP1 has been linked to mitotic errors, genomic instability, and diseases such as cancer, making it a target for studying tumorigenesis and therapeutic strategies.

Antibodies against MKLP1 are widely used in cell biology research to visualize its localization (e.g., midbody staining via immunofluorescence) or quantify _expression (e.g., Western blotting). They help investigate MKLP1's functional roles in cell cycle regulation, its interaction partners, and its potential as a biomarker. These antibodies are typically raised in hosts like rabbits or mice, available as monoclonal or polyclonal versions. Validation steps, including knockout controls and functional assays, ensure specificity. Researchers also utilize MKLP1 inhibitors or siRNA alongside antibodies to explore its mechanistic contributions to mitosis, cancer progression, and drug resistance.