GMPR2抗体—艾普蒂 新品

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     Western blot analysis using GMPR2 mouse mAb against  Hep G2 lysate    

  
  

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     Lane 1: GMPR2 immunoprecipitated from Hep G2 lysate by P16249;  Lane 2: The same as Lane 2 but use IgG isotype control antibody;  Result: P16249 can immunoprecipitate GMPR2.    

  
  

The GMPR2 (Guanosine Monophosphate Reductase 2) antibody is a tool used to detect and study the GMPR2 protein, an enzyme involved in purine metabolism. GMPR2 catalyzes the NADPH-dependent reduction of GMP to IMP, playing a role in maintaining nucleotide pool balance. Unlike its paralog GMPR1. which is broadly expressed, GMPR2 exhibits tissue-specific expression, with higher levels in the liver, kidney, and testes. Research on GMPR2 is limited but growing, as dysregulation of purine metabolism is linked to metabolic disorders, immune dysfunction, and cancer.

The antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It enables applications such as Western blotting, immunohistochemistry, and immunofluorescence to analyze GMPR2 expression, localization, and regulation. Studies suggest GMPR2 may act as a tumor suppressor in certain cancers, with reduced expression correlating with poor prognosis. Its interaction with metabolic pathways also highlights potential roles in drug resistance and cellular stress responses. Validation of GMPR2 antibodies includes specificity checks via knockout controls and cross-reactivity assessments. This tool aids in elucidating GMPR2's biological significance and therapeutic potential.