IFNA1抗体—艾普蒂

+ +

•  

   

     Result: P16179 can detect human IFNA1 by Western blotting.    

  
  

Interferon alpha-1 (IFNA1) is a member of the type I interferon (IFN) family, a group of cytokines critical in innate immune responses against viral infections and immune regulation. IFNA1 binds to the IFN-α/β receptor (IFNAR), activating the JAK-STAT signaling pathway to induce expression of interferon-stimulated genes (ISGs) that mediate antiviral, antiproliferative, and immunomodulatory effects. Antibodies targeting IFNA1 are valuable tools for studying its biological functions, expression patterns, and therapeutic potential.

IFNA1 antibodies are commonly used in research applications such as ELISA, Western blot (WB), immunohistochemistry (IHC), and flow cytometry to detect endogenous IFNA1 protein levels in cell cultures, tissues, or biological fluids. They help elucidate IFNA1's role in diseases like autoimmune disorders (e.g., systemic lupus erythematosus), cancers, and viral infections (e.g., hepatitis, COVID-19). Some antibodies neutralize IFNA1 activity, enabling functional studies to dissect its contributions to pathological or protective immune responses.

Both monoclonal and polyclonal IFNA1 antibodies are available, with specificity validated through knockout controls or blocking assays. Researchers select antibodies based on host species, clonality, and application compatibility. Cross-reactivity with other IFN-α subtypes must be considered due to structural similarities. Commercial IFNA1 antibodies often include recombinant proteins for competitive validation. Beyond basic research, these reagents hold potential for diagnostic assays or therapeutic development, particularly in conditions where dysregulated IFN signaling drives disease progression.