LMOD1抗体—艾普蒂

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     Western blot analysis using LMOD1 mouse mAb against  rat uterus tissue lysate    

  
  

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     Lane 1: Rat uterus tissue lysate;  Lane 2: LMOD1 immunoprecipitated from rat uterus tissue lysate by P16172;  Lane 3: The same as Lane 2 but use IgG isotype control antibody;Result: P16172 can immunoprecipitate LMOD1;    

  
  

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     IHC-P analysis of endometrial smooth muscle tissue by LMOD1 antibody (P16172) IHC-P was performed using sections of the formalin-fixed paraffin-embedded endometrial smooth muscle tissue;Result: Smooth muscle cells are positively stained at the cytoplasm.    

  
  

**Background of LMOD1 Antibody**

LMOD1 (Leiomodin 1) is a member of the leiomodin family of actin-binding proteins, primarily expressed in smooth muscle cells and skeletal muscle. It plays a critical role in regulating actin cytoskeleton dynamics by promoting the elongation of thin filaments and stabilizing filamentous actin (F-actin) structures. LMOD1 is essential for maintaining muscle contractility and structural integrity, particularly in vascular and respiratory systems.

The LMOD1 antibody is a tool used to detect and study the expression, localization, and function of LMOD1 in various biological contexts. Research has linked LMOD1 dysregulation to human diseases, including congenital myopathies, thoracic aortic aneurysms, and pulmonary arterial hypertension. For instance, LMOD1 mutations are associated with severe muscle weakness and respiratory insufficiency in infants, highlighting its clinical relevance.

In laboratory settings, LMOD1 antibodies are employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate LMOD1’s role in muscle development, disease mechanisms, and potential therapeutic targets. Recent studies also explore its interaction with other cytoskeletal proteins, such as tropomyosin and tropomodulin, to elucidate its regulatory pathways.

Overall, LMOD1 antibodies serve as vital reagents for advancing understanding of muscle biology, cytoskeletal disorders, and related genetic or acquired conditions. Their application continues to drive discoveries in both basic research and translational medicine.