Human Lambda抗体—艾普蒂 新品

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     IHC-P analysis of tonsil tissue by Lambda antibody (P16110) IHC-P was performed using sections of the formalin-fixed paraffin-embedded tonsil tissue;Result: Subset of lymph cells are positively stained at cytoplasm.    

  
  

Human lambda antibodies are a class of immunoglobulins characterized by their lambda (λ) light chains, which pair with heavy chains to form antigen-binding sites. In humans, antibodies contain two types of light chains: lambda and kappa (κ), with lambda light chains constituting approximately 40% of all antibodies. The lambda light chain is encoded by a gene cluster on chromosome 22. involving variable (V), joining (J), and constant (C) gene segments that recombine during B-cell development to generate diversity.

Lambda antibodies play a critical role in adaptive immunity, recognizing pathogens through their variable regions and neutralizing or tagging them for destruction. Their production follows a hierarchical process: B-cells typically attempt kappa light chain rearrangement first, switching to lambda if kappa rearrangement fails. This ensures functional antibody diversity.

Clinically, lambda light chains are significant in diagnosing monoclonal gammopathies, such as multiple myeloma, where abnormal lambda or kappa chain ratios (serum free light chain assays) aid in disease detection and monitoring. Additionally, lambda-containing antibodies are utilized in therapeutic monoclonal antibody development, where light chain selection impacts antigen affinity and stability. Research into lambda antibody biology continues to explore their structural uniqueness, genetic regulation, and role in autoimmune diseases, enhancing both diagnostic and therapeutic applications.