GSTA1抗体—艾普蒂

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     IHC-P analysis of liver tissue by GSTA1 antibody (P16090) IHC-P was performed using sections of the formalin-fixed paraffin-embedded liver tissue;Result: Hepatocytes cells are positively stained at the cytoplasm.    

  
  

The glutathione S-transferase Alpha 1 (GSTA1) antibody is a tool used to detect and study the GSTA1 protein, a member of the glutathione S-transferase (GST) family. GSTs are phase II detoxification enzymes that catalyze the conjugation of glutathione to electrophilic compounds, facilitating their metabolism and excretion. GSTA1. specifically expressed in the liver, kidneys, and gastrointestinal tract, plays a critical role in neutralizing reactive oxygen species (ROS), xenobiotics, and carcinogens. It is implicated in cellular protection against oxidative stress, drug metabolism, and inflammation regulation.

Dysregulation of GSTA1 has been linked to various diseases, including liver disorders, cancer, and neurodegenerative conditions. For instance, reduced GSTA1 activity may enhance susceptibility to toxin-induced damage, while its overexpression in certain tumors is associated with chemoresistance. The GSTA1 antibody is widely utilized in research applications such as Western blotting, immunohistochemistry (IHC), and ELISA to assess protein expression levels, tissue localization, and disease mechanisms. It aids in exploring GSTA1's role in detoxification pathways, biomarker discovery, and therapeutic target validation. Antibodies targeting GSTA1 are typically produced in hosts like rabbits or mice, with validation for specificity and sensitivity across experimental models. Understanding GSTA1 dynamics through such tools contributes to advancements in toxicology, oncology, and precision medicine.