HEATR4抗体—艾普蒂

The HEATR4 antibody targets the HEAT repeat-containing protein 4 (HEATR4), a member of the HEAT-repeat superfamily characterized by tandem repeats of alpha-helical motifs involved in protein-protein interactions. HEATR4 is implicated in transcriptional regulation, cell cycle control, and DNA damage repair. It is highly expressed in the testis and certain cancer tissues, suggesting roles in germ cell development and tumorigenesis. Research links HEATR4 to ciliogenesis, as it localizes to the basal body of primary cilia and may regulate ciliary assembly or stability. Dysregulation of HEATR4 has been observed in cancers, including gliomas and prostate cancer, where it may influence proliferation or genomic instability. Antibodies against HEATR4 are utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression patterns, subcellular localization, and interactions in normal and pathological contexts. These tools help unravel HEATR4's functional mechanisms, its potential as a biomarker, and its therapeutic relevance in ciliopathies or malignancies. Commercial HEATR4 antibodies are typically validated for specificity using knockout controls or siRNA-based depletion.