CAPSL抗体—艾普蒂 新品

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     IHC-P analysis of fallopian tube tissue by CAPSL antibody (P16023) IHC-P was performed using sections of the formalin-fixed paraffin-embedded fallopian tube tissue;Result: The roots of cilia are positively stained.    

  
  

The CAPSL (Calcium-dependent secretion activator-like protein) antibody is associated with autoimmune disorders, particularly type 1 diabetes (T1D) and rheumatoid arthritis (RA). CAPSL, a protein encoded by the *CAPSL* gene, is implicated in cellular secretion pathways and immune regulation. Research identified CAPSL as an autoantigen when antibodies targeting it were detected in patient sera, suggesting its role in autoimmune pathogenesis.

In T1D, anti-CAPSL antibodies have been proposed as potential biomarkers for early disease prediction, appearing alongside classic autoantibodies like GAD65 or IA-2. Their presence may reflect immune dysregulation targeting pancreatic β-cells. Similarly, in RA, CAPSL antibodies correlate with disease activity, hinting at their involvement in synovial inflammation.

The exact mechanism remains unclear, but CAPSL's calcium-binding properties and role in secretory processes suggest it may influence antigen presentation or immune cell communication. Studies using immunoassays and animal models continue to explore its functional relevance. While not yet standardized in clinical diagnostics, CAPSL antibodies represent a promising research focus for understanding autoimmune mechanisms and improving diagnostic or prognostic tools. Further validation is needed to establish their clinical utility and pathogenic significance.