TTC3抗体—艾普蒂 新品

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     IHC-P analysis of brain tissue by TTC3 antibody (P16005) IHC-P was performed using sections of the formalin-fixed paraffin-embedded brain tissue;Result: Neuropil and cytoplasm of neuronal cells are positively stained.    

  
  

The TTC3 antibody is a research tool designed to detect the Tetratricopeptide Repeat Domain 3 (TTC3) protein, encoded by the *TTC3* gene located on human chromosome 21 (21q22.2). TTC3 is of particular interest due to its position within the Down Syndrome Critical Region (DSCR), a segment of chromosome 21 triplicated in individuals with Down syndrome (trisomy 21). The protein contains tetratricopeptide repeat (TPR) motifs, which mediate protein-protein interactions, and a RING finger domain, suggesting E3 ubiquitin ligase activity. TTC3 is implicated in ubiquitination pathways, potentially regulating protein degradation and cellular processes like neurodevelopment.

Studies link TTC3 dysfunction to neurodevelopmental and neurodegenerative phenotypes observed in Down syndrome, including intellectual disability and early-onset Alzheimer's-like pathology. It interacts with key signaling pathways (e.g., mTOR, AKT) and may influence neuronal dendrite development, synaptic plasticity, and stress responses. TTC3 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression, localization, and role in disease models. Research continues to explore its molecular mechanisms, particularly its involvement in ubiquitin-mediated proteostasis and its contribution to the pathophysiology of chromosome 21-associated disorders.