TBC1D17抗体—艾普蒂 新品

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     IHC-P analysis of heart muscle tissue by TBC1D17 antibody (P15992) IHC-P was performed using sections of the formalin-fixed paraffin-embedded heart muscle tissue;Result: Cardiomyocytes are positively stained at the cytoplasm.    

  
  

**Background of TBC1D17 Antibody**

TBC1D17 is a member of the Tre-2/Bub2/Cdc16 (TBC) domain-containing protein family, known for their roles as GTPase-activating proteins (GAPs) targeting Rab GTPases, which regulate intracellular vesicle trafficking and membrane dynamics. TBC1D17 specifically functions as a GAP for Rab5 and Rab4. influencing endosomal sorting, receptor recycling, and autophagy. Studies suggest its involvement in cellular processes like glucose uptake, insulin signaling, and lysosomal biogenesis, often interacting with pathways such as mTORC1.

The TBC1D17 antibody is a critical tool for detecting and studying the expression, localization, and function of TBC1D17 in various biological contexts. It is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its subcellular distribution (e.g., endosomes, Golgi) and post-translational modifications. Research highlights its relevance in metabolic disorders, cancer, and neurodegenerative diseases, where dysregulated Rab signaling or autophagy may contribute to pathology.

Developed and validated across species (human, mouse), the antibody aids in elucidating TBC1D17’s regulatory mechanisms, such as phosphorylation-dependent interactions with 14-3-3 proteins or its role in stress responses. Its specificity and reliability make it essential for exploring TBC1D17 as a potential therapeutic target or biomarker in disease models.