LSP1抗体—艾普蒂

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     IHC-P analysis of tonsil tissue by LSP1 antibody (P15913) IHC-P was performed using sections of the formalin-fixed paraffin-embedded tonsil tissue;Result: A part of germinal center cells and non-germinal center cells are positively stained at the cytoplasm and cell membrane.    

  
  

**Background of LSP1 Antibody**

Leukocyte-Specific Protein 1 (LSP1), also known as WP34 or S37. is a cytoskeleton-associated protein predominantly expressed in immune cells, including neutrophils, macrophages, B cells, and T cells. It plays a critical role in regulating cell motility, adhesion, and migration by interacting with F-actin and signaling molecules involved in cytoskeletal reorganization. LSP1 contains multiple phosphorylation sites and structural domains, such as the Src homology 3 (SH3)-binding motifs, enabling its participation in intracellular signaling pathways triggered by chemokines, cytokines, or integrin activation.

LSP1 antibodies are essential tools for studying immune cell behavior and inflammatory responses. They are widely used in techniques like Western blotting, immunofluorescence, and flow cytometry to detect LSP1 expression, localization, and post-translational modifications. Research has linked LSP1 dysfunction to pathological conditions, such as chronic inflammatory diseases, immunodeficiency disorders, and cancer metastasis, highlighting its role in modulating immune cell infiltration and tumor microenvironment interactions.

In mouse models, LSP1 knockout studies reveal impaired neutrophil chemotaxis and reduced immune cell recruitment to infection sites, underscoring its importance in host defense. Commercially available LSP1 antibodies are often validated across species (human, mouse, rat) to support translational research, aiding in the exploration of LSP1's dual roles in pro-inflammatory and anti-tumor immunity.