CDH15抗体—艾普蒂

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     Western blot analysis using CDH15 mouse mAb against  HeLa lysate and mouse brain tissue lysate    

  
  

CDH15 antibody targets Cadherin-15 (CDH15), a calcium-dependent cell adhesion molecule belonging to the cadherin superfamily. Cadherins play critical roles in tissue morphogenesis, cellular recognition, and intercellular adhesion. CDH15. also known as M-cadherin, is predominantly expressed in skeletal muscle and neural tissues, where it facilitates myoblast fusion during muscle development and maintains neuromuscular junction integrity. Its expression is tightly regulated during embryogenesis and muscle regeneration, highlighting its importance in myogenic differentiation and tissue repair.

Research on CDH15 antibodies has gained traction due to their utility in studying muscle-related disorders, such as muscular dystrophies, and neurological conditions linked to synaptic dysfunction. These antibodies enable detection of CDH15 in immunoassays (e.g., Western blot, immunohistochemistry) and are instrumental in exploring its interaction with cytoskeletal proteins like β-catenin. Aberrant CDH15 expression has also been implicated in cancers, including colorectal carcinoma and rhabdomyosarcoma, where it may influence tumor invasiveness or metastasis.

Recent studies emphasize CDH15's potential as a biomarker for muscle regeneration capacity or neuromuscular disease progression. However, its precise signaling mechanisms and therapeutic relevance remain under investigation. CDH15 antibodies thus serve as vital tools for unraveling its biological roles and translational applications in regenerative medicine and oncology.