NGDN抗体—艾普蒂 新品

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     IHC-P analysis of placenta tissue by NGDN antibody (P15880) IHC-P was performed using sections of the formalin-fixed paraffin-embedded placenta tissue;Result: Trophoblastic cells and decidual cells are positively stained at the cytoplasm and cell membrane.    

  
  

**Background of NGDN Antibodies**

Neuroguidin (NGDN), a conserved eukaryotic protein, plays a critical role in regulating mRNA translation and synaptic plasticity. Initially identified in *Drosophila*, it interacts with translation initiation factors (e.g., eIF4E) and components of the nonsense-mediated decay (NMD) pathway, linking localized protein synthesis to neuronal development and function. NGDN is particularly vital in neurons, where it supports dendritic spine formation, axonal growth, and synaptic efficacy by modulating translation dynamics in response to synaptic activity.

NGDN antibodies are essential tools for studying its expression, localization, and molecular interactions. They enable detection via techniques like Western blot, immunohistochemistry, and immunoprecipitation, aiding research on NGDN's role in neurodevelopment and disease. Dysregulation of NGDN has been implicated in neurological disorders, including autism spectrum disorders (ASD) and intellectual disability, as well as cancer progression due to its influence on cell proliferation and stress responses.

Studies using NGDN antibodies have revealed its phosphorylation-dependent interactions and tissue-specific isoforms, highlighting evolutionary conservation across species. These antibodies also facilitate exploration of NGDN’s interplay with mTOR and other signaling pathways, offering insights into potential therapeutic targets. Overall, NGDN antibodies are pivotal in unraveling the protein’s multifunctional roles in cellular and neurological contexts.