HPGDS抗体—艾普蒂 新品

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     IHC-P analysis of lung tissue by HPGDS antibody (P15877) IHC-P was performed using sections of the formalin-fixed paraffin-embedded lung tissue;Result: Macrophages are positively stained at the cytoplasm.    

  
  

The hematopoietic prostaglandin D synthase (HPGDS) is a key enzyme in the biosynthesis of prostaglandin D2 (PGD2), a lipid mediator involved in inflammation, allergy, and immune regulation. Belonging to the glutathione S-transferase family, HPGDS catalyzes the conversion of prostaglandin H2 (PGH2) to PGD2. which interacts with specific receptors (DP1 and DP2) to modulate cellular responses. HPGDS is predominantly expressed in hematopoietic cells, including mast cells, Th2 lymphocytes, and dendritic cells, and is implicated in allergic diseases (e.g., asthma, atopic dermatitis), neuroinflammation, and cancer progression.

HPGDS antibodies are essential tools for detecting and quantifying this enzyme in research and diagnostics. They enable the study of HPGDS expression patterns, cellular localization, and regulatory mechanisms via techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry. These antibodies are often developed in hosts such as rabbits or mice, targeting specific epitopes to ensure specificity. Validation steps, including knockout controls and functional assays, are critical to confirm their reliability. In therapeutic contexts, HPGDS inhibitors are explored for allergic and inflammatory diseases, making corresponding antibodies valuable for preclinical evaluations. Additionally, HPGDS's dual role in neuroprotection and neurodegeneration highlights its relevance in neurological research. High-quality HPGDS antibodies thus support advances in understanding immune pathways, disease mechanisms, and targeted drug development.