FYB1抗体—艾普蒂 新品

+ +

•  

   

     Lane 1: U-937 lysate;  Lane 2: FYB1 immunoprecipitated from U-937 lysate by P15873;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15873 can immunoprecipitate FYB1;    

  
  

FYB1 (FYN Binding Protein 1), also known as ADAP (Adhesion and Degranulation Promoting Adaptor Protein), is a cytoplasmic adaptor protein predominantly expressed in immune cells, including T cells, natural killer (NK) cells, and platelets. It plays a critical role in regulating immune cell signaling, adhesion, and activation. Structurally, FYB1 contains multiple domains, such as SH3-binding motifs and a proline-rich region, enabling interactions with signaling molecules like FYN kinase and SKAP1. These interactions facilitate the formation of signaling complexes involved in T-cell receptor (TCR)-mediated signaling, integrin activation, and cytoskeletal reorganization.

FYB1 antibodies are essential tools for studying its function in immune responses. They are widely used in techniques like Western blotting, flow cytometry, and immunofluorescence to detect FYB1 expression, localization, and interactions in cellular models. Research has linked FYB1 dysregulation to immune-related pathologies, including autoimmune diseases (e.g., rheumatoid arthritis) and platelet disorders, due to its role in modulating integrin activation and immune synapse formation. Recent studies also explore FYB1's involvement in cancer immunology, particularly its impact on tumor-infiltrating lymphocytes and immune evasion mechanisms. These antibodies thus provide insights into both basic immunology and potential therapeutic targets.