ARID4B抗体—艾普蒂 新品

The ARID4B (AT-rich interaction domain 4B) antibody is a research tool designed to detect and study the ARID4B protein, a member of the ARID (AT-rich interaction domain) family. ARID4B, also known as RBBP1-like or SAP180. plays roles in chromatin remodeling, transcriptional regulation, and epigenetic modifications. It interacts with retinoblastoma-associated proteins (e.g., RB1) and histone deacetylase complexes, influencing cell cycle progression, differentiation, and apoptosis. Dysregulation of ARID4B has been linked to cancers (e.g., breast, prostate) and neurodevelopmental disorders, though its exact mechanisms remain under investigation. Studies suggest it may act as both oncogene and tumor suppressor, depending on cellular context. The ARID4B antibody is commonly used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to explore its expression patterns, subcellular localization, and interactions. Commercially available antibodies are typically developed in rabbit or mouse hosts, targeting specific epitopes within conserved regions of the human or murine protein. Validation includes testing for specificity via knockdown/knockout controls. Its applications span basic research in gene regulation, cancer biology, and developmental disorders, aiding in mechanistic studies of ARID4B's role in disease pathways and potential therapeutic targeting.