NPTXR抗体—艾普蒂

The neuronal pentraxin receptor (NPTXR) is a synaptic protein belonging to the neuronal pentraxin family, which includes secreted glycoproteins involved in synaptic plasticity and neural development. NPTXR is primarily localized at excitatory synapses and interacts with other pentraxins like NP1 and NPR to mediate the clustering of AMPA-type glutamate receptors, facilitating synaptic transmission and remodeling. Structurally, it contains an N-terminal pentraxin domain and a C-terminal transmembrane region, distinguishing it from secreted family members. Antibodies targeting NPTXR are critical tools for studying its expression, localization, and functional roles in both physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate synaptic organization in brain tissues or neuronal cultures. Research has linked NPTXR dysregulation to neurodevelopmental disorders (e.g., autism spectrum disorders), neurodegenerative diseases (e.g., Alzheimer’s), and psychiatric conditions, where synaptic dysfunction is a hallmark. These antibodies also aid in exploring NPTXR's potential as a biomarker or therapeutic target, particularly in conditions involving impaired synaptic connectivity or neuroinflammation.