CRYAA抗体—艾普蒂

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     IHC-P analysis of lens tissue by CRYAA antibody (P15849) IHC-P was performed using sections of the formalin-fixed paraffin-embedded lens tissue;Result: Lens fiber cells are positively stained.    

  
  

**Background of CRYAA Antibody**

CRYAA (αA-crystallin) is a small heat shock protein (sHSP) belonging to the crystallin family, primarily expressed in the eye lens and certain muscle tissues. It plays a critical role in maintaining lens transparency and cellular proteostasis by acting as a molecular chaperone, preventing the aggregation of misfolded proteins under stress conditions. CRYAA forms hetero-oligomers with its homolog, αB-crystallin (CRYAB), enhancing its stability and functional versatility.

Mutations in the *CRYAA* gene are linked to congenital cataracts and other ocular pathologies, while its dysregulation has been implicated in neurodegenerative diseases and cancers. CRYAA antibodies are essential tools for studying its expression, localization, and interactions in both physiological and disease contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to investigate CRYAA's role in lens development, stress response, and disease mechanisms.

Research utilizing CRYAA antibodies has advanced understanding of its dual roles in structural lens integrity and cytoprotection, highlighting its potential as a therapeutic target for cataracts and protein-aggregation-related disorders.