MLH3抗体—艾普蒂

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     IHC-P analysis of endometrium tissue by MLH3 antibody (P15846) IHC-P was performed using sections of the formalin-fixed paraffin-embedded endometrium tissue;Result: Glandular cells and stromal cells are positively stained at the nuclei.    

  
  

The MLH3 antibody is a crucial tool for studying the MLH3 protein, a key component of the DNA mismatch repair (MMR) system. MLH3 (MutL homolog 3) partners with proteins like PMS2 to form the MutLγ heterodimer, which plays a role in correcting DNA replication errors, particularly insertion-deletion mismatches. It also interacts with MSH2-MSH3 complexes during MMR and contributes to meiotic recombination by facilitating crossover formation. Dysregulation or mutations in MLH3 are linked to hereditary cancers, such as Lynch syndrome, and infertility due to impaired gametogenesis.

MLH3 antibodies, typically monoclonal or polyclonal, enable detection of MLH3 expression and localization via techniques like immunohistochemistry, Western blotting, and immunofluorescence. Their specificity is often validated using MLH3-knockout controls. Researchers use these antibodies to investigate MLH3's role in maintaining genomic stability, its association with tumorigenesis, and its impact on reproductive health. In clinical contexts, MLH3 antibody-based assays aid in diagnosing MMR-deficient cancers and understanding genetic predispositions to malignancies. Recent studies also explore MLH3's potential involvement in autoimmune disorders and its interplay with other DNA repair pathways, underscoring its multifaceted biological significance.