OPALIN抗体—艾普蒂 新品

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     IHC-P analysis of brain tissue by OPALIN antibody (P15804) IHC-P was performed using sections of the formalin-fixed paraffin-embedded brain tissue;Result: Neuropil is positively stained.    

  
  

OPALIN, also known as Synaptotagmin-like protein 1 (SYTL1) or Sling-1. is a transmembrane protein predominantly expressed in oligodendrocytes within the central nervous system (CNS). It was first identified in 2001 as a molecule enriched at the paranodal loops of myelinating oligodendrocytes, where it plays a role in maintaining the structural integrity of myelin sheaths. OPALIN is localized to the late endosomal and lysosomal compartments, suggesting its involvement in membrane trafficking and vesicle dynamics during myelination. Studies in mice have shown that OPALIN deficiency leads to subtle myelination defects, though its exact molecular mechanisms remain under investigation.

OPALIN antibodies are valuable tools in neuroscience research, particularly for studying oligodendrocyte biology, myelination processes, and demyelinating disorders like multiple sclerosis. These antibodies enable the visualization of OPALIN expression patterns in CNS tissues via immunohistochemistry or immunofluorescence. Western blotting using OPALIN antibodies typically detects a ~50 kDa protein band. Recent research has explored OPALIN's potential role in lipid metabolism and its interactions with other myelin-related proteins, making its antibodies relevant for both basic and translational studies. However, commercial availability of validated OPALIN antibodies remains limited, requiring careful validation for experimental specificity.