MC4R抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11016(MC4R Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P11016(MC4R Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The melanocortin-4 receptor (MC4R), a G protein-coupled receptor (GPCR) primarily expressed in the hypothalamus, plays a central role in regulating energy homeostasis, appetite, and body weight. It is activated by α-melanocyte-stimulating hormone (α-MSH) and inhibited by agouti-related peptide (AgRP), forming a key pathway in leptin-mediated signaling. Dysregulation of MC4R is strongly linked to obesity, diabetes, and metabolic disorders, with MC4R mutations being the most common monogenic cause of severe early-onset obesity in humans.

MC4R antibodies are essential tools for studying receptor expression, localization, and function in both physiological and pathological contexts. They enable detection of MC4R protein levels in tissues, cell cultures, or animal models, aiding research into receptor trafficking, post-translational modifications, and interaction with ligands or downstream effectors. Additionally, these antibodies are used to validate MC4R-targeted therapies, including agonists and antagonists in development for obesity treatment.

In pharmacological studies, MC4R antibodies help elucidate mechanisms of receptor activation, desensitization, and biased signaling. Their applications extend to diagnostic research, such as identifying MC4R mutations in genetic obesity screening, and to preclinical studies evaluating drug efficacy. As obesity remains a global health challenge, MC4R antibodies continue to support advances in understanding metabolic regulation and therapeutic innovation.