LAMA5抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10988(LAMA5 Antibody) at dilution 1/8. (Original magnification: ×200)    

  
  

The LAMA5 antibody is a crucial tool in biomedical research targeting the laminin subunit alpha 5 (LAMA5), a key component of laminin-511/521. a major extracellular matrix protein in basement membranes. LAMA5 plays essential roles in tissue development, cell adhesion, migration, and signaling by interacting with integrins and other cell surface receptors. It is particularly vital during embryogenesis, organogenesis, and maintaining tissue homeostasis in adults. Dysregulation of LAMA5 expression is linked to pathologies such as cancer progression, fibrosis, and kidney diseases.

Antibodies against LAMA5 are widely used to study its expression patterns, localization, and function in normal and diseased tissues. They enable techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize LAMA5 distribution in cellular and animal models. Researchers also employ these antibodies to investigate LAMA5's role in tumor microenvironment remodeling, epithelial-mesenchymal transition (EMT), and angiogenesis. Commercially available LAMA5 antibodies are typically raised in hosts like rabbits or mice, validated for specificity through knockout controls or siRNA silencing. Challenges include ensuring cross-reactivity across species (e.g., human, mouse) and distinguishing between laminin isoforms due to structural homology. Recent studies focus on LAMA5 as a potential therapeutic target or biomarker, driving demand for high-affinity, well-characterized antibodies.