KCNC1抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: P10986(KCNC1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10986(KCNC1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The KCNC1 antibody is a research tool targeting the Kv3.1 protein, a voltage-gated potassium channel encoded by the KCNC1 gene. Kv3.1 channels are prominently expressed in fast-spiking neurons, such as cerebellar Purkinje cells and brainstem nuclei, where they enable rapid repolarization of action potentials, ensuring high-frequency firing and precise neuronal signaling. These channels play a critical role in maintaining excitability and synchronization within neural circuits.

KCNC1 antibodies are widely used in neuroscience to investigate Kv3.1’s expression patterns, subcellular localization, and functional alterations in health and disease. Common applications include Western blotting, immunohistochemistry, and immunofluorescence. Researchers also employ these antibodies to explore links between Kv3.1 dysfunction and neurological disorders, such as spinocerebellar ataxia, epilepsy, and hearing loss, as KCNC1 mutations or dysregulation have been implicated in these conditions.

Commercial KCNC1 antibodies are typically raised against specific epitopes, often in rodents or rabbits. Validation data confirming reactivity with human, mouse, or rat samples are crucial for experimental reliability. Some antibodies distinguish between Kv3.1 splice variants (e.g., Kv3.1a and Kv3.1b), which exhibit differential expression across brain regions. As potassium channel modulators gain attention in drug development, KCNC1 antibodies remain vital for elucidating Kv3.1’s pathophysiological roles and therapeutic potential. Proper controls, such as knockout tissue, are recommended to confirm specificity in detection assays.