IRF7抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10974(IRF7 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10974(IRF7 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

Interferon Regulatory Factor 7 (IRF7) is a critical transcription factor in the innate immune response, primarily regulating type I interferon (IFN-α/β) production during viral infections. As a member of the IRF family, it is activated through pathogen-sensing pathways like Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs). IRF7 exists in inactive forms under basal conditions but undergoes phosphorylation and dimerization upon viral detection, enabling nuclear translocation and transcriptional activation of IFN genes. Its expression is tightly regulated, with low baseline levels in most cells, except plasmacytoid dendritic cells, where it is constitutively expressed to ensure rapid antiviral responses.

Antibodies targeting IRF7 are essential tools for studying its expression, localization, and activation mechanisms. They are widely used in techniques such as Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and flow cytometry. These antibodies help elucidate IRF7’s role in immune signaling, host-pathogen interactions, and diseases like autoimmune disorders or cancers. Commercial IRF7 antibodies are often validated for specificity using knockout cell lines or siRNA-mediated silencing. Researchers also employ phospho-specific antibodies to detect activated IRF7. providing insights into post-translational modifications during immune activation. Dysregulation of IRF7 has been linked to impaired antiviral defense and chronic inflammation, underscoring its therapeutic relevance.