IGFBP3抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10964(IGFBP3 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10964(IGFBP3 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

Insulin-like growth factor-binding protein 3 (IGFBP3) is a key member of the IGFBP family, primarily involved in regulating the bioavailability and activity of insulin-like growth factors (IGFs), particularly IGF-I and IGF-II. By binding to IGFs with high affinity, IGFBP3 modulates their interaction with cell surface receptors, thereby influencing cellular processes such as proliferation, differentiation, and apoptosis. It also exhibits IGF-independent functions, including direct effects on cell nuclei and interaction with other proteins.

Antibodies targeting IGFBP3 are essential tools in biomedical research and diagnostics. They are widely used in techniques like Western blotting, ELISA, and immunohistochemistry (IHC) to detect IGFBP3 expression levels in tissues or biological fluids. These antibodies help investigate IGFBP3's roles in diseases such as cancer (where it may act as a tumor suppressor or promoter depending on context), growth disorders, and metabolic syndromes.

Structurally, IGFBP3 contains distinct N- and C-terminal domains critical for IGF binding and protein-protein interactions. Antibodies are often designed to recognize specific epitopes within these regions. Both monoclonal and polyclonal IGFBP3 antibodies are available, with selection depending on application-specific needs. Validation of antibody specificity is crucial, as cross-reactivity with other IGFBPs may occur.

Research highlights IGFBP3's dual role in apoptosis regulation and its potential as a biomarker for conditions like prostate cancer or diabetes. Its interplay with p53 and involvement in senescence pathways further underscore its biological significance. Reliable IGFBP3 antibodies thus remain vital for unraveling its complex functions in health and disease.