HOXD13抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse bladder tissue, Primary antibody: P10959(HOXD13 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

The HOXD13 antibody is a crucial tool in developmental biology and genetic research, targeting the HOXD13 protein encoded by the *HOXD13* gene, a member of the homeobox (HOX) gene family. HOX genes are evolutionarily conserved regulators of embryonic development, particularly in establishing body patterning and limb formation. HOXD13. located on chromosome 2q31. plays a pivotal role in autopod (distal limb) development and digit specification, as well as urogenital system morphogenesis. Mutations in *HOXD13* are linked to human disorders such as synpolydactyly (SPD) and hand-foot-genital syndrome (HOS), characterized by limb malformations and genital abnormalities.

The HOXD13 antibody is widely used to detect and quantify HOXD13 protein expression in various experimental models, including immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF). It aids in studying HOXD13's spatial-temporal expression during embryogenesis, its interaction with signaling pathways (e.g., SHH, FGF), and its role in transcriptional regulation of target genes. Researchers also employ this antibody to investigate HOXD13 dysregulation in congenital defects, cancer (e.g., leukemia, colorectal cancer), and regenerative processes. Both polyclonal and monoclonal variants are available, with validation often performed using knockout controls or overexpression systems. Its utility extends to diagnostic applications, helping correlate genetic mutations with phenotypic outcomes in clinical samples.