HOXA11抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse muscle tissue, Primary antibody: P10957(HOXA11 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

The HOXA11 antibody is a crucial tool in studying the HOXA11 protein, encoded by the *HOXA11* gene within the HOX gene family. HOX genes are evolutionarily conserved transcription factors that regulate embryonic development, particularly body patterning and organogenesis. HOXA11 is specifically involved in limb development, urogenital system formation, and female reproductive tract differentiation. Its expression is tightly regulated during embryogenesis but may reappear in certain pathological contexts, such as cancers.

HOXA11 antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein localization, expression levels, and interactions. Research highlights its dual roles: in development, it guides uterine and limb morphogenesis, while in oncology, aberrant HOXA11 expression is linked to ovarian, endometrial, and cervical cancers. It may act as a tumor suppressor or promoter depending on the cancer type and microenvironment.

Clinically, HOXA11 dysregulation is associated with endometriosis, infertility, and congenital uterine anomalies. Antibodies against HOXA11 aid in exploring these mechanisms, offering insights into diagnostic or therapeutic strategies. However, variability in antibody specificity (due to protein isoforms or post-translational modifications) requires careful validation. Overall, HOXA11 antibodies remain vital for dissecting developmental pathways and disease mechanisms, bridging basic research and translational applications.