HMGB2抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, Raw264.7 cells, Primary antibody: P10953(HMGB2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

**Background of HMGB2 Antibody**

The High Mobility Group Box 2 (HMGB2) protein is a non-histone chromatin-associated protein belonging to the HMGB family, which plays critical roles in DNA repair, recombination, transcription regulation, and chromatin remodeling. HMGB2 is highly expressed in embryonic tissues and certain cancer cells, where it contributes to cell proliferation, differentiation, and survival. Its function is closely linked to its ability to bind DNA and modulate chromatin structure, facilitating interactions between transcription factors and DNA.

HMGB2-specific antibodies are essential tools for studying its expression, localization, and interactions in cellular processes. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect HMGB2 in tissue samples, cultured cells, or experimental models. Research has highlighted HMGB2's involvement in cancer progression, stem cell biology, and inflammatory responses, with studies suggesting its potential as a biomarker or therapeutic target.

Antibodies targeting HMGB2 are typically validated for specificity against its conserved domains, distinguishing it from homologous family members like HMGB1. Their applications extend to investigating HMGB2's extracellular roles, where it may act as a damage-associated molecular pattern (DAMP) molecule, promoting inflammation or immune activation. Understanding HMGB2 dynamics through antibody-based assays continues to advance insights into developmental biology, oncogenesis, and regenerative medicine.