HCN1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: P10941(HCN1 Antibody) at dilution 1/950, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10941(HCN1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The HCN1 antibody is a crucial tool for studying the hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1), a member of the HCN channel family that regulates electrical activity in excitable cells. HCN1 channels, encoded by the HCN1 gene, are voltage-gated ion channels activated by membrane hyperpolarization and modulated by cyclic nucleotides. They contribute to the generation of rhythmic activity in neurons and cardiac cells, playing roles in pacemaker currents, synaptic integration, and neuronal excitability. HCN1 is predominantly expressed in the brain (e.g., cortex, hippocampus) and, to a lesser extent, in the heart.

HCN1-specific antibodies enable researchers to detect, localize, and quantify HCN1 protein expression in tissues or cell cultures. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate HCN1's functional roles in physiological and pathological contexts. Dysregulation of HCN1 has been implicated in neurological disorders (e.g., epilepsy, neuropathic pain) and cardiac arrhythmias, making its study clinically relevant. The development of high-specificity, validated HCN1 antibodies is essential for distinguishing HCN1 from other HCN isoforms (HCN2-4), which share structural similarities but differ in activation kinetics and tissue distribution. Commercial antibodies often target unique epitopes within the N- or C-terminal regions of the HCN1 protein to ensure specificity.