GPR3抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: SKOV3, A172 and Jurkat cell lysates, Primary antibody: P10928(GPR3 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

The GPR3 antibody is a research tool designed to target G protein-coupled receptor 3 (GPR3), a member of the G protein-coupled receptor (GPCR) family. GPR3 is constitutively active, signaling primarily through Gαs proteins to elevate intracellular cAMP levels, and is highly expressed in the central nervous system (CNS), particularly in neurons. It has been implicated in physiological processes such as neuronal differentiation, synaptic plasticity, and the maintenance of resting cAMP levels. Notably, GPR3 is linked to neurodegenerative diseases, including Alzheimer’s disease (AD), where it may influence β-amyloid production and tau phosphorylation.

GPR3 antibodies are used to detect, localize, and quantify the receptor in tissues or cell lines, aiding studies on its expression patterns and functional roles. These antibodies are typically validated via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF), often targeting specific epitopes (e.g., extracellular or intracellular domains). Researchers employ GPR3 antibodies to explore its involvement in disease mechanisms, such as AD progression, or to evaluate therapeutic strategies targeting GPCR signaling pathways. Challenges include ensuring antibody specificity due to structural similarities among GPCRs. Recent studies highlight GPR3’s potential as a therapeutic target, driving demand for reliable antibodies to advance molecular and translational research.