PPBP抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human plasma solution, Primary antibody: P10907(PPBP Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P10907(PPBP Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10907(PPBP Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The PPBP (Pro-Platelet Basic Protein) antibody targets a protein encoded by the *PPBP* gene, which belongs to the CXC chemokine family. PPBP, also known as CXCL7. is primarily synthesized in megakaryocytes and stored in platelet α-granules. Upon platelet activation, it is released and proteolytically processed into bioactive forms, including neutrophil-activating peptide-2 (NAP-2), connective tissue-activating peptide III (CTAP-III), and β-thromboglobulin. These peptides play roles in inflammation, wound healing, and thrombosis by recruiting neutrophils, promoting angiogenesis, and modulating immune responses.

PPBP is implicated in pathologies such as atherosclerosis, cancer metastasis, and thromboembolic disorders due to its dual role in promoting inflammation and tissue repair. In cancer, PPBP-derived peptides may enhance tumor progression by stimulating angiogenesis or immunosuppressive microenvironments.

Antibodies against PPBP are valuable tools for detecting its expression in platelets, plasma, or tissues via techniques like ELISA, Western blot, or immunohistochemistry. They help elucidate PPBP's involvement in disease mechanisms and its potential as a biomarker for platelet activation or inflammatory conditions. Research also explores its therapeutic relevance, particularly in targeting chemokine-driven pathways in thrombosis or cancer. However, its multifunctional nature requires careful interpretation of experimental data to distinguish between physiological and pathological roles.