GABRR1抗体—艾普蒂

The GABA-A receptor subunit ρ1 (GABRR1) is a key component of the ionotropic GABA-A receptor family, which mediates inhibitory neurotransmission in the central nervous system. Unlike most GABA-A receptors composed of α, β, and γ subunits, receptors containing ρ subunits (ρ1-3) form homomeric or heteromeric complexes and are often classified as GABA-A-ρ or GABA-C receptors. GABRR1 is primarily expressed in the retina, brainstem, and spinal cord, where it contributes to synaptic plasticity, visual processing, and modulation of neuronal excitability. Antibodies targeting GABRR1 are essential tools for studying its expression, localization, and functional roles in physiological and pathological contexts. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to map receptor distribution in tissues or investigate changes in neurological disorders, such as epilepsy, schizophrenia, and retinal degenerative diseases. Additionally, GABRR1-specific antibodies aid in elucidating receptor trafficking, post-translational modifications, and interactions with therapeutic compounds. Due to structural similarities among GABA-A subunits, antibody specificity is critically validated using knockout models or competitive assays. Research on GABRR1 continues to explore its potential as a therapeutic target and its involvement in sensory processing pathways.