IGF2BP1抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane: Hela cells, Primary antibody: P10875(IGF2BP1 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10875(IGF2BP1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P10875(IGF2BP1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The IGF2BP1 antibody is a key tool for studying the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), a member of the conserved RNA-binding protein family. IGF2BP1. also known as IMP1 or ZBP1. regulates mRNA stability, localization, and translation by binding to target transcripts via its KH domains. It plays critical roles in embryonic development, cell polarity, and tumorigenesis. Dysregulation of IGF2BP1 is linked to cancers, where its overexpression correlates with poor prognosis, metastasis, and therapy resistance in malignancies like colorectal, ovarian, and lung cancers.

The antibody detects IGF2BP1 in techniques such as Western blot, immunohistochemistry, and immunofluorescence, aiding research into its oncogenic mechanisms. Specific clones (e.g., D7T7M) are validated for human, mouse, or rat samples, with applications in studying RNA-protein interactions, post-transcriptional gene regulation, and cancer biomarkers. Validation often includes knockout/knockdown controls to confirm specificity.

Research using IGF2BP1 antibodies has highlighted its role in stabilizing oncogenic mRNAs (e.g., MYC, HMGA2) and promoting cancer stemness. Its dual role in development and disease makes it a focus for therapeutic targeting. However, variability in antibody performance across species or experimental conditions requires careful optimization. Overall, IGF2BP1 antibodies are vital for exploring RNA biology and developing cancer diagnostics or therapies.