FOXN1 抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P10868(FOXN1  Antibody) at dilution 1/15. (Original magnification: ×200)    

  
  

FOXN1 (Forkhead Box N1) is a transcription factor critical for thymus development and skin homeostasis. It regulates the differentiation and maintenance of thymic epithelial cells (TECs), which are essential for T-cell maturation. FOXN1 also plays a role in hair follicle formation and epidermal differentiation. Mutations in the *FOXN1* gene are linked to human nude severe combined immunodeficiency (SCID), characterized by hairlessness and T-cell deficiency, underscoring its biological importance.

FOXN1 antibodies are essential tools for studying its expression, localization, and function. These antibodies enable detection of FOXN1 protein in tissues like the thymus, skin, and hair follicles via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers use them to investigate FOXN1's role in TEC development, T-cell selection, and regenerative processes. Additionally, FOXN1 antibodies aid in exploring its regulatory mechanisms, including interactions with downstream targets like *DLL4* and *CXCL12*, which mediate thymopoiesis.

In disease research, FOXN1 antibodies help model immunodeficiency disorders and evaluate therapeutic strategies, such as thymus regeneration therapies. Their specificity and reliability are validated through knockout controls or peptide-blocking assays. Overall, FOXN1 antibodies are pivotal in immunology, developmental biology, and dermatology research, bridging molecular insights with clinical applications.