FOXC2抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human breast infiltrative duct tissue, Primary antibody: P10858(FOXC2 Antibody) at dilution 1/733, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

The FOXC2 antibody is a tool used to detect and study the FOXC2 protein, a member of the Forkhead box (FOX) family of transcription factors. FOXC2 plays critical roles in embryonic development, particularly in the formation of lymphatic vessels, mesenchymal cell differentiation, and lipid metabolism. It is also implicated in regulating epithelial-mesenchymal transition (EMT), a process linked to cancer metastasis and fibrosis. Mutations in the FOXC2 gene are associated with hereditary lymphedema-distichiasis syndrome, characterized by abnormal lymphatic system development and accessory eyelashes.

FOXC2 antibodies are widely utilized in research to investigate protein expression patterns, subcellular localization, and functional mechanisms in both normal and diseased tissues. They are essential in techniques like Western blotting, immunohistochemistry, and immunofluorescence. In cancer biology, FOXC2 antibodies help explore its role in tumor progression, drug resistance, and metastasis. However, antibody specificity and batch variability can pose challenges, necessitating validation using knockout controls or complementary assays.

The development of FOXC2 antibodies has advanced studies on metabolic disorders, lymphatic diseases, and cancer, offering insights into potential therapeutic targets. Despite progress, understanding FOXC2's complex regulatory networks and context-dependent functions remains an ongoing focus in biomedical research.