FAF1抗体—艾普蒂

+ +

•  

   

     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: P10845(FAF1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10845(FAF1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10845(FAF1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of FAF1 Antibody**

FAF1 (Fas-associated factor 1) is a multidomain protein involved in regulating apoptosis, inflammation, and proteostasis. Initially identified as a Fas death receptor-interacting protein, FAF1 modulates apoptosis by interacting with components of the ubiquitin-proteasome system (e.g., VCP/p97) and stress response pathways. It contains domains like UBA, UBX, and FAS1. enabling interactions with diverse partners, including caspases, chaperones, and ubiquitin-related proteins.

FAF1 antibodies are critical tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate FAF1’s role in diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. For instance, FAF1 dysregulation has been linked to tumor suppression, neuronal apoptosis in Alzheimer’s disease, and immune response modulation.

These antibodies target specific epitopes or domains (e.g., N-terminal or C-terminal regions), aiding in distinguishing FAF1 isoforms. Validation includes testing in knockout models or siRNA-treated cells to ensure specificity. Commercially available as monoclonal or polyclonal variants, FAF1 antibodies support both basic research and clinical studies, offering insights into its dual roles as a pro-apoptotic regulator and a potential therapeutic target.