DUSP8抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P10843(DUSP8 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P10843(DUSP8 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P10843(DUSP8 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The DUSP8 antibody is a research tool designed to detect and analyze the dual-specificity phosphatase 8 (DUSP8), a member of the mitogen-activated protein kinase (MAPK) phosphatase (MKP) family. DUSP8. also known as hVH-5. functions as a negative regulator of MAPK signaling pathways, particularly targeting c-Jun N-terminal kinase (JNK) and p38 MAPK. It modulates cellular responses to stress, inflammation, and growth signals by dephosphorylating and inactivating these kinases. Structurally, DUSP8 contains an N-terminal catalytic domain and a C-terminal substrate-binding domain, enabling its interaction with specific MAPKs.

DUSP8 is expressed in various tissues, including the brain, immune cells, and endocrine organs, and plays roles in neuroendocrine regulation, immune response, and metabolic processes. Studies link DUSP8 dysregulation to diseases such as obesity, diabetes, neurodegenerative disorders, and cancer. For instance, it may influence insulin signaling and neuronal survival, while its aberrant expression in tumors suggests a context-dependent role in oncogenesis.

The DUSP8 antibody is essential for investigating its expression patterns, post-translational modifications, and interactions in experimental models (e.g., Western blotting, immunohistochemistry). Researchers rely on validated antibodies to ensure specificity, as cross-reactivity with other DUSP family members can complicate results. Ongoing research aims to clarify DUSP8's therapeutic potential, particularly in targeting MAPK-driven pathologies. Proper antibody selection and experimental design are critical for advancing understanding of DUSP8's biological and clinical significance.