SLC1A1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta tissue and normal liver tissue, Primary antibody: P10821(SLC1A1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 4 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10821(SLC1A1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10821(SLC1A1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SLC1A1 gene encodes the excitatory amino acid transporter 3 (EAAT3), a transmembrane protein responsible for the uptake of glutamate, the primary excitatory neurotransmitter in the central nervous system. As a high-affinity glutamate transporter, EAAT3 plays a critical role in maintaining synaptic glutamate homeostasis, preventing neurotoxicity from excessive extracellular glutamate accumulation. SLC1A1 antibodies are specifically designed to detect and study the expression, localization, and function of this transporter in various tissues, particularly in neurons and epithelial cells.

Research involving SLC1A1 antibodies has been pivotal in exploring neurological and psychiatric disorders linked to glutamate dysregulation, such as obsessive-compulsive disorder (OCD), schizophrenia, and epilepsy. These antibodies enable immunohistochemical, Western blot, or immunofluorescence techniques to visualize EAAT3 distribution in brain regions like the striatum, hippocampus, and cortex. Additionally, studies using SLC1A1 antibodies have revealed its extra-neuronal roles, including nutrient absorption in the gut and kidney.

Dysfunctional EAAT3 activity, detected via antibody-based assays, is associated with altered glutamate signaling pathways, providing insights into disease mechanisms and potential therapeutic targets. The development of reliable SLC1A1 antibodies continues to support advances in understanding glutamate transporter biology and its implications in health and disease.