MIP抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10787(MIP Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10787(MIP Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

MIP (Major Intrinsic Protein) antibodies are essential tools for studying the structure and function of aquaporin-0 (AQP0), a critical protein in maintaining lens transparency in the eye. Belonging to the aquaporin family, MIP/AQP0 forms transmembrane channels that regulate water and small solute transport across cell membranes. It is predominantly expressed in lens fiber cells, where it ensures optical clarity by mediating cell-to-cell adhesion and osmotic balance. Mutations or dysregulation of MIP are linked to cataracts, making it a key focus in ophthalmic research.

MIP antibodies enable the detection, localization, and quantification of AQP0 in various experimental models, including immunohistochemistry, Western blotting, and immunofluorescence. They aid in exploring MIP's role in lens development, homeostasis, and disease mechanisms. Recent studies also investigate its potential involvement in non-ocular tissues, such as the brain and tumors, expanding its biomedical relevance.

These antibodies are pivotal for developing diagnostic tools and therapeutic strategies targeting cataract formation and other MIP-associated pathologies. Their specificity and reliability continue to support advancements in understanding membrane protein dynamics and cellular physiology.