GJA9抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal muscle tissue, Primary antibody: P10785(GJA9 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

The GJA9 antibody targets the gap junction protein alpha 9 (GJA9), also known as connexin 59 (Cx59) in some species or connexin 50 (Cx50) in humans, a member of the connexin family. Connexins form intercellular channels called gap junctions, enabling direct communication between adjacent cells by transferring ions, metabolites, and signaling molecules. GJA9 is primarily expressed in the lens of the eye, where it plays a critical role in maintaining lens transparency and homeostasis. Mutations in the GJA9 gene have been linked to congenital cataracts, highlighting its importance in ocular physiology.

GJA9 antibodies are essential tools in studying the protein’s expression, localization, and function. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to investigate GJA9 distribution in tissues, particularly in lens epithelial cells and fiber cells. Research utilizing these antibodies has advanced understanding of gap junction dynamics in lens development, cataractogenesis, and potential regenerative therapies.

Beyond the eye, GJA9 antibodies have exploratory applications in detecting ectopic expression in other tissues, though its primary role remains ocular-focused. Studies also employ these antibodies to probe pathological mechanisms in genetically engineered animal models of cataracts. Despite its niche focus, GJA9 research underscores the broader significance of connexins in cellular communication and disease, bridging basic science and clinical insights into vision disorders.