CCN2抗体—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and HepG2 cell lysates, Primary antibody: P10780(CCN2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P10780(CCN2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The CCN2 antibody targets connective tissue growth factor (CTGF/CCN2), a matricellular protein belonging to the CCN family (Cyr61. CTGF, Nov). CCN2 plays critical roles in cell proliferation, adhesion, migration, and extracellular matrix (ECM) remodeling, particularly during tissue repair and fibrotic processes. It interacts with growth factors like TGF-β, integrins, and ECM components, mediating pathways involved in fibrosis, angiogenesis, and wound healing. Dysregulated CCN2 expression is linked to pathological conditions, including diabetic nephropathy, hepatic fibrosis, systemic sclerosis, and cancer progression.

CCN2 antibodies are essential tools for detecting and quantifying CCN2 in techniques such as Western blotting, immunohistochemistry, ELISA, and immunofluorescence. They enable researchers to study CCN2's expression patterns, localization, and functional roles in disease models. Both monoclonal and polyclonal variants are available, with monoclonal antibodies offering high specificity and polyclonal antibodies providing broader epitope recognition. Neutralizing CCN2 antibodies further allow mechanistic studies by blocking its biological activity.

Research using CCN2 antibodies has advanced understanding of fibrotic pathways and therapeutic targeting. Inhibiting CCN2 has emerged as a potential strategy to mitigate fibrosis and tumor metastasis. However, challenges remain, such as ensuring antibody specificity due to structural similarities among CCN family members. Overall, CCN2 antibodies remain pivotal in elucidating the protein's dual roles in tissue homeostasis and disease pathogenesis.