COL4A1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P10771(COL4A1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P10771(COL4A1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

COL4A1 antibodies target the alpha-1 chain of type IV collagen, a critical component of basement membranes in various tissues, including blood vessels, kidneys, and eyes. Encoded by the COL4A1 gene, this collagen forms a structural network with COL4A2. providing mechanical stability and regulating cellular processes like adhesion and signaling. Mutations in COL4A1 are linked to multisystem disorders, such as hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC syndrome), cerebrovascular disease, and familial porencephaly. These mutations disrupt collagen assembly, leading to fragile vasculature and tissue dysfunction.

COL4A1 antibodies are essential tools in research and diagnostics. They help detect COL4A1 expression, localization, and abnormalities in tissue samples via techniques like immunohistochemistry, Western blotting, and immunofluorescence. Commercially available polyclonal or monoclonal antibodies often recognize specific epitopes, aiding in studying COL4A1-related pathologies. In preclinical models, these antibodies are used to explore disease mechanisms, such as microvascular defects or renal dysfunction, and to validate gene-editing approaches.

Their clinical relevance extends to identifying COL4A1 mutations in patients with unexplained stroke, kidney disease, or ocular anomalies, enabling personalized management. However, standardized protocols for antibody validation are crucial due to potential cross-reactivity with other collagen isoforms. Overall, COL4A1 antibodies bridge molecular insights into basement membrane biology and translational applications in heritable connective tissue disorders.