CNGA1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10763(CNGA1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of CNGA1 Antibody**

The **CNGA1 antibody** is a specialized tool used to detect and study the **cyclic nucleotide-gated channel alpha-1 subunit (CNGA1)**, a critical component of ion channels in the retina and other tissues. CNGA1 forms homotetrameric or heterotetrameric channels with other subunits (e.g., CNGB1) and is essential for phototransduction in **rod photoreceptor cells**. These channels open in response to cyclic guanosine monophosphate (cGMP), enabling the flow of cations (Na⁺, Ca²⁺) that depolarize the cell membrane, initiating visual signaling.

CNGA1 antibodies are widely employed in **neuroscience** and **ophthalmology research** to investigate retinal function, congenital vision disorders (e.g., retinitis pigmentosa), and channelopathies. They are used in techniques like **Western blotting**, **immunohistochemistry (IHC)**, and **immunofluorescence (IF)** to localize CNGA1 expression, assess protein levels, or study mutations linked to disease.

Mutations in the *CNGA1* gene are associated with **autosomal recessive retinitis pigmentosa (ARRP)** and impaired night vision. Antibodies targeting specific epitopes (e.g., N-terminal, cytoplasmic regions) help dissect structural-functional relationships or validate gene-editing outcomes in models. Commercial CNGA1 antibodies are typically raised in rabbits or mice, with validation in knockout controls to ensure specificity. Their applications extend to exploring retinal degeneration mechanisms and potential therapies targeting CNG channels.