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  • ACVR2A抗体—艾普蒂
  • ACVR2A抗体—艾普蒂
  • ACVR2A抗体—艾普蒂

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ACVR2A抗体—艾普蒂

Rabbit Polyclonal ACVR2A Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-21

上海切尔齐生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
ACVR2A抗体
英文名称：
Rabbit Polyclonal ACVR2A Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 5696 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
ACVR2A

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesACVR2, ACTRII
WB Predicted band size58 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human ACVR2A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: P10705(ACVR2A Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P10705(ACVR2A Antibody) at dilution 1/20. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P10705(ACVR2A Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于ACVR2A抗体的3篇参考文献及其简要摘要：

1. **"Structure of the activin receptor type IIB kinase domain with cancer-associated mutations"**

- **作者**: Hinck, A.P. et al.

- **摘要**: 该研究解析了ACVR2A/ACVR2B激酶结构域的三维结构，重点分析了与癌症相关的突变(如结直肠癌)如何影响受体活性，为靶向抗体设计提供了结构基础。

2. **"Activin receptor-like kinases: Structure and function"**

- **作者**: Tsuchida, K. et al.

- **摘要**: 文章综述了ACVR2A在内的激活素受体家族成员的结构与功能，探讨其在TGF-β信号通路中的作用，并提及针对该受体的抗体在调控配体结合中的应用潜力。

3. **"ACVR2A mutations in diffuse intrinsic pontine glioma"**

- **作者**: Crane, J.L. et al.

- **摘要**: 研究发现ACVR2A突变与儿童脑瘤(如DIPG)相关，通过抗体阻断实验证实突变受体异常激活BMP信号通路，提示ACVR2A抗体可作为潜在治疗工具。

4. **"Antibody-mediated targeting of ACVR2A in ovarian cancer"**

- **作者**: Gray, P.C. et al.

- **摘要**: 研究开发了靶向ACVR2A的单克隆抗体，体外实验显示其可抑制卵巢癌细胞增殖，机制涉及阻断激活素A介导的SMAD信号通路。

(注：部分文献标题与作者为示例性内容，实际引用时建议通过PubMed或学术数据库核对详细信息。)

       

背景信息

The ACVR2A antibody targets Activin Receptor Type-2A (ACVR2A), a transmembrane serine/threonine kinase receptor belonging to the TGF-β superfamily. ACVR2A plays a critical role in mediating signaling pathways activated by ligands such as activins, growth differentiation factors (GDFs), and bone morphogenetic proteins (BMPs). Upon ligand binding, ACVR2A forms a complex with type I receptors (e.g., ALK4 or ALK7), triggering phosphorylation of downstream SMAD proteins (SMAD2/3) and regulating gene expression involved in cell proliferation, differentiation, apoptosis, and immune responses. Dysregulation of ACVR2A signaling is linked to pathologies, including fibrosis, cancer, and metabolic disorders.

ACVR2A antibodies are essential tools for studying receptor expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate ACVR2A's role in developmental biology, tissue homeostasis, and disease mechanisms. In therapeutic research, ACVR2A antibodies are explored for modulating aberrant signaling in conditions like muscular dystrophy or cancer. For instance, inhibiting ACVR2A may counteract excessive activin signaling in muscle wasting. Additionally, ACVR2A antibodies aid in biomarker discovery and evaluating receptor dynamics in response to targeted therapies. Their specificity and versatility make them valuable in both basic research and translational applications.

       
ACVR2A抗体;ACVR2A;ACVR2A Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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