RAB5C抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P10673(RAB5C Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P10673(RAB5C Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The RAB5C antibody is a crucial tool in studying the RAB5C protein, a member of the Rab GTPase family involved in regulating intracellular membrane trafficking. RAB5C specifically controls early endosome dynamics, including vesicle formation, motility, and fusion, which are essential for endocytosis, signal transduction, and organelle biogenesis. Dysregulation of RAB5C is linked to diseases such as cancer and neurodegenerative disorders, making it a target for biomedical research.

The antibody enables detection and localization of RAB5C in cells or tissues via techniques like Western blotting, immunofluorescence, and immunohistochemistry. It helps elucidate RAB5C's role in cellular processes, including receptor internalization, autophagy, and pathogen invasion. Commercial RAB5C antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions), and validated for specificity using knockout controls.

Researchers also use RAB5C antibodies to explore its interaction with effectors (e.g., EEA1. Rabaptin-5) and its GTP/GDP cycling mechanism. In cancer studies, RAB5C overexpression is associated with metastasis, highlighting its potential as a therapeutic biomarker. Overall, this antibody serves as a vital reagent for dissecting membrane trafficking pathways and their implications in health and disease.